本文在相同的实验条件下,在阳离子交换柱上比较了α-羟基α-甲基丁酸(HMBA)和α-羟基异丁酸(HIBA)为淋洗剂分离Am(Ⅲ),Cm(Ⅲ)的性能。实验测得对HIBA体系,Am(Ⅲ)-Cm(Ⅲ)的分离因子为1.37,与文献值基本一致;而对HMBA体系,其分离因子为1.71,此值与我们测定的络合常数相吻合,从而确证以HMBA淋洗分离Am(Ⅲ)-Cm(Ⅲ)远较HIBA优良。为了使HMBA成为实用的淋洗剂,我们还研究了影响分离效果的各种因素。 In this paper, the separation of Am (Ⅲ), Cm (Ⅲ) from α-hydroxy α-methylbutyric acid (HMBA) and α-hydroxyisobutyric acid ) Performance. The experimental results showed that the separation factor of Am (Ⅲ) -Cm (Ⅲ) was 1.37 in HIBA system, which was basically the same as the literature value. For HMBA system, the separation factor was 1.71, which was consistent with our determination of the complexing constant , Which confirmed that the HMBA leaching Am (Ⅲ) -Cm (Ⅲ) is far superior to HIBA. In order to make HMBA a practical eluent, we also studied various factors that affect the separation.