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采用不同尺寸的聚四氟乙烯(PTFE)微管为内外管、玻璃毛细管(glass capillary)或聚丙烯(PP)中空纤维为内管管头设计制作了一种共轴微通道反应器(N-CAMFR).以聚乳酸(PLA)/二氯甲烷(CH2Cl2)溶液和海藻酸钠(Na-alginate)水溶液分别作为分散相,在N-CAMFR内形成O/W和W/O乳液后,收集乳液并使其中的液滴固化,制备出单分散的生物质聚合物微珠(BPM).研究了固定管头尺寸时,改变连续相的流速及表面活性剂的种类对微珠尺寸的影响.结果表明,使用N-CAMFR制备微珠,反应过程流畅,所制得的微珠粒径分布均匀,其分散系数(f)可低至2.16%;通过改变内管管头的尺寸可方便地调控N-CAMFR的尺度,与传统微通道反应器相比,降低制作成本的同时拓宽了其应用的范围,而且降低了微通道反应器堵塞的几率.为粒径范围200~800μm的单分散聚合物微珠的可控连续制备提供了快捷绿色的新方法.
A coaxial microchannel reactor (N- (4-hydroxyethyl) piperazine) was designed and manufactured by using PTFE microtubules with different sizes for inner and outer tubes, glass capillary or PP hollow fiber as inner tube headers. CAMFR) After the O / W and W / O emulsions were formed in N-CAMFR using PLA / CH2Cl2 solution and Na-alginate as the dispersed phase respectively, the emulsion was collected And the droplets were solidified to prepare monodispersed biomass polymer beads (BPM) .The influence of the flow rate of the continuous phase and the type of the surfactant on the size of the microbeads was studied when the size of the fixed head was fixed.Results The results showed that the beads prepared by N-CAMFR had a smooth reaction process. The prepared beads had uniform particle size distribution with a dispersion coefficient (f) as low as 2.16%. By changing the size of the inner tube head, N -CAMFR scale, compared with the traditional microchannel reactor, reducing the production cost while broaden the scope of its application, and reduce the chance of microchannel reactor plugging.For the particle size range of 200 ~ 800μm monodisperse polymer micro Controllable continuous preparation of beads provides a quick and green new method.