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目的:测定慢性肾衰竭患者血清脂联素水平,分析它在慢性肾衰竭患者心血管病变发生发展中的作用及可能机制。方法:以临床心血管事件为标准,将慢性肾衰患者(64例)分为A、B两组,C组为正常对照组,采用ELISA法测定血清脂联素水平,同时测定体重指数、血脂、高敏C反应蛋白等相关指标。结果:A、B两组血清脂联素水平明显高于C组,B组低于A组,且脂联素与体重指数、甘油三酯、高敏C反应蛋白呈负相关,与肌酐、高密度脂蛋白呈正相关。结论:慢性肾衰患者血清脂联素水平较健康者普遍升高,且合并心血管事件者较未合并心血管事件者血清脂联素降低,低脂联素血症可能为慢性肾衰患者心血管病变的预测因子。
Objective: To determine the level of serum adiponectin in patients with chronic renal failure and to analyze its possible role in the development of cardiovascular disease in patients with chronic renal failure. Methods: The patients with chronic renal failure (64 cases) were divided into A and B groups according to clinical cardiovascular events. C group was normal control group. Serum adiponectin level was measured by ELISA. BMI, , High-sensitivity C-reactive protein and other related indicators. Results: Serum adiponectin levels in group A and group B were significantly higher than those in group C, group B was lower than group A, and adiponectin was negatively correlated with body mass index, triglyceride and high sensitive C - reactive protein, and creatinine, high density Lipoprotein was positively correlated. Conclusion: Serum levels of adiponectin in patients with chronic renal failure are generally higher than those in healthy controls. Serum adiponectin levels are lower in patients with cardiovascular events than in those without cardiovascular events. Predictors of vascular disease.