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目的探讨多层螺旋CT灌注成像在孤立性肺结节良性、炎性、恶性诊断及鉴别诊断中的意义。方法利用6层MSCT灌注成像技术研究45例直径2~4cm的孤立性肺结节灌注表现。采用CTPerfusion胸部肿瘤灌注软件包,测定肺内病灶的血容量(BV)、血流量(BF)、对比剂到达峰值时间(TTP)、强化峰值(PEI)和时间-密度曲线(TDC),并在其基础上计算出强化值、SPN与主动脉增强峰值之比值(S/A)。结果恶性结节和炎性结节的BF、BV、和PEI值均明显高于良性结节,有显著性差异,恶性结节与炎性结节之间的灌注值则无显著性差异,TTP值三者之间也无显著性意义。恶性结节、良性结节、炎性结节时间-密度曲线(TDC)均显示形态不同。恶性结节和炎性结节强化值、S/A值高于良性结节,有显著性差异(P<0.05)。结论MSCT灌注成像有助于良、恶性肺结节诊断及鉴别诊断。
Objective To investigate the significance of multislice spiral CT perfusion imaging in the diagnosis, differential diagnosis of solitary pulmonary nodules. Methods Six-layer MSCT perfusion imaging was used to study the performance of solitary pulmonary nodules in 45 patients with diameter 2-4 cm. Blood volume (BV), blood flow (BF), peak contrast time (TTP), peak PEI and time-density curve (TDC) were measured using a CTPerfusion chest tumor perfusion software package. Based on this, the fortified value and the ratio of SPN to aortic enhancement peak (S / A) were calculated. Results The BF, BV and PEI values of malignant and inflammatory nodules were significantly higher than those of benign nodules, there was a significant difference between the malignant and inflammatory nodules perfusion value was no significant difference, TTP The value of the three no significant significance. Malignant nodules, benign nodules, inflammatory nodule time-density curve (TDC) showed morphological differences. Malignant nodules and inflammatory nodules enhanced value, S / A value higher than benign nodules, there was a significant difference (P <0.05). Conclusion MSCT perfusion imaging is helpful for the diagnosis and differential diagnosis of benign and malignant pulmonary nodules.