甲状腺激素受体 (TR)为核受体超家族的成员 ,其分子中含有A～F 6个区 ,组成 3个功能域。TR有若干异形体 ,其中TRα1、TRβ1和TRβ2可结合T3 ,为功能性受体。一些甲状腺激素拟似剂虽能与TR结合但不能激活TR ,可作为TR的拮抗剂。大多数TRα和 (或 )TRβ基因剔除的小鼠都可存活 ,其表型甚至接近野生型。 Thyroid hormone receptor (TR) is a member of the nuclear receptor superfamily, which contains 6 domains of A ~ F in the molecule and consists of 3 domains. TR has a number of different forms, of which TRα1, TRβ1 and TRβ2 can be combined with T3, as a functional receptor. Although some thyroid hormone mimics can bind to TR but can not activate TR, they can be used as antagonists of TR. Most mice that had TRα and / or TRβ knockout survived and their phenotype even approached that of the wild type.