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用国产甲氟哌酸(PF)对14例新发多菌型麻风治疗6个月,临床、皮肤查菌、组织病理学和菌血症检查均有明显进步。对其中9例于治疗前后测定麻风菌的活力,显示治疗1个月有2例繁殖,2和3个月时则均耒见繁殖。2例BL分别治疗6和12个月停药,前者停药10个月、后者停药4个月随访时病情恶化,提示治疗不足或有产生耐PF菌株的可能性。
14 cases of new-onset multi-bacterium leprosy were treated with domestic norfloxacin (PF) for 6 months. Clinical, dermatological examination, histopathology and bacteremia were all significantly improved. The activity of leprosy was measured in 9 of them before and after treatment, which showed that there were 2 cases of reproduction in 1 month and 2 days and 3 months. Two cases of BL were treated for 6 and 12 months respectively, the former discontinued for 10 months and the latter discontinued for 4 months. The condition deteriorated during the follow-up period, which indicated the possibility of insufficient treatment or PF-resistant strains.