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对正常人41名,轻度和重度萎缩性胃炎各36例和20例,胃癌33例的胃液中β-葡萄糖醛酸酶(β-G)、亮氨酸氨基肽酶(LAP)及乳酸脱氢酶(LDH)的活力进行了测定。结果表明三组β-G、LAP和LDH的活力都比对照组高,有非常显著差异(P<0.001)。其中以胃癌组增高最为显著。按Rogers等的方法处理,以对照组三项酶活力最高数值立方根之和“23”作为判定指数(discriminatingindex),凡超过此指数者判为恶变阳性。胃癌组阳性率为94％。在胃癌诊断上应用三项酶活力的判定值比使用单项酶更有价值。
41 normal persons, 36 cases of mild and severe atrophic gastritis, 20 cases of gastric atrophy, 33 cases of gastric cancer, β-glucuronidase (β-G), leucine aminopeptidase (LAP) and lactate The activity of hydrogenase (LDH) was measured. The results showed that the activity of the three groups of β-G, LAP and LDH was higher than that of the control group, and there was a very significant difference (P<0.001). The most significant increase was in the gastric cancer group. According to the method of Rogers et al., the “23” sum of the highest cube roots of the three enzyme activities in the control group was used as a discriminating index. Those who exceeded this index were judged to be malignant. The positive rate of gastric cancer was 94%. The determination of the use of three enzyme activities in the diagnosis of gastric cancer is more valuable than the use of a single enzyme.