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目的研究伊木萨克片和盐酸氟西汀联合治疗早泄的可行性和效果。方法将114例早泄患者随机分为3组,每组38例。A组患者单用伊木萨克片,1.5 g/d;B组患者单用盐酸氟西汀,20 mg/d;C组患者同时服用伊木萨克片和盐酸氟西汀,剂量同A、B组,连续服用4周。比较3组治疗前后的平均阴道内射精潜伏期(IELT)、国际勃起功能指数(IIEF)问卷中的患者及配偶性交满意度评分,观察治疗期间的不良反应。结果 114例早泄患者全部完成临床研究,所有患者平均IELT、患者及其配偶的性交满意度评分在治疗后较治疗前均显著增加,差异具统计学意义(P<0.01),单用盐酸氟西汀B组患者的IELT和性交满意度评分略好于单用药伊木萨克片A组,但两组间差异无统计学意义(P>0.05)。联合用药C组患者的IELT和性交满意度评分则显著高于单用药A组和B组,差异均具有统计学意义(P<0.05)。联合用药患者出现不良反应7例(18.4%),与单用药组比较差异无统计学意义。结论联合应用伊木萨克片和盐酸氟西汀治疗早泄,疗效显著高于单用两种药物。
Objective To study the feasibility and effect of combining the treatment of moxibustion with fluoxetine and moxibustion on the premature ejaculation. Methods 114 cases of premature ejaculation were randomly divided into 3 groups, 38 cases in each group. The patients in group A were treated with xamoxetine alone (1.5 g / d), the patients in group B received fluoxetine hydrochloride alone (20 mg / d), and the patients in group C took both xamoxifen and fluoxetine Group, taking 4 consecutive weeks. The mean intravaginal ejaculation latency (IELT), the scores of sexual intercourse satisfaction of couples and their partners in the IIEF questionnaire before and after treatment were compared to observe the adverse reactions during the treatment. Results A total of 114 patients with premature ejaculation completed the clinical study. The scores of sexual satisfaction of all patients with IELT, patients and their spouses were significantly increased after treatment compared with those before treatment (P <0.01) The scores of IELT and intercourse satisfaction in group B were slightly better than those in group A, but there was no significant difference between the two groups (P> 0.05). The scores of IELT and sexual intercourse satisfaction in group C with combination therapy were significantly higher than those in group A and group B, with statistical significance (P <0.05). There were 7 adverse reactions (18.4%) in the combination group and there was no significant difference compared with the single drug group. Conclusions The combined use of moxibacl and fluoxetine hydrochloride in the treatment of premature ejaculation, the curative effect is significantly higher than the single use of two drugs.