论文部分内容阅读
目的:研究纳洛酮治疗慢性阻塞性肺疾病(COPD)Ⅱ型呼吸衰竭患者脑电图异常的疗效。方法:141例COPDⅡ型呼吸衰竭且脑电图异常者随机分为2组,试验组71例,给予纳洛酮2mg每日1次静脉滴注;对照组70例,给予尼可刹米1.125g和洛贝宁9mg每日1次静脉滴注,疗程均为7d,对比2组治疗前、后脑电图及动脉血气分析变化。结果:试验组在纠正缺氧、减少二氧化碳潴留方面较对照组改善显著(P=0.01,P=0.02);试验组与对照组脑电图改善有效率分别为85.9%、67.1%,差异有统计学意义(P=0.008)。结论:纳洛酮组治疗COPDⅡ型呼吸衰竭患者后脑电图好转优于对照组,效果显著,未发现不良反应。
Objective: To study the effect of naloxone on EEG abnormalities in patients with chronic obstructive pulmonary disease (COPD) type Ⅱ respiratory failure. Methods: 141 cases of COPD type Ⅱ respiratory failure and abnormal EEG were randomly divided into two groups, the experimental group of 71 cases, given naloxone 2mg daily intravenous infusion; control group of 70 patients given nicorandracen 1.125g And Lobelin 9mg daily intravenous infusion, treatment were 7d, compared with two groups before and after treatment, EEG and arterial blood gas analysis changes. Results: The experimental group improved significantly (P = 0.01, P = 0.02) compared with the control group in ameliorating hypoxia and reducing carbon dioxide retention. The effective rates of EEG in experimental group and control group were 85.9% and 67.1%, respectively Significance (P = 0.008). Conclusion: The improvement of electroencephalogram in Naloxone group after treatment of COPD patients with type 2 respiratory failure is better than that of control group, and the effect is remarkable. No adverse reaction was found.