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目的探讨游离前列腺特异性抗原和总前列腺特异性抗原比率（Ｆ／ＴＰＳＡ）对前列腺疾病临床诊断的意义。方法用微粒子捕捉酶免分析法（ＭＥＩＡ），检测前列腺增生症６６例、前列腺癌１５例及正常组６０例的血清ＦＰＳＡ、ＴＰＳＡ浓度及其比率，所得数据进行统计学分析。结果前列腺癌组ＦＰＳＡ／ＴＰＳＡ平均比率为７．１８％，前列腺增生组平均为１９．８７％，正常对照组为３１．８２％。结论前列腺癌病例ＦＰＳＡ／ＴＰＳＡ比率均小于１０％，因此，ＦＰＳＡ／ＴＰＳＡ比率可更有效地诊断前列腺癌，当ＴＰＳＡ浓度为小于２０ｕｇ／ｌ时，测定其比率有相当大的临床意义。
Objective To investigate the clinical significance of free prostate specific antigen and total prostate specific antigen ratio (F / TPSA) in the diagnosis of prostatic diseases. Methods The serum levels of FPSA, TPSA and their ratios in 66 cases of benign prostatic hyperplasia, 15 cases of prostatic carcinoma and 60 cases of normal prostate cancer were detected by microparticle capture enzyme immunoassay (MEIA). The data were statistically analyzed. Results The average ratio of FPSA / TPSA was 7.18% in prostate cancer group, 19.87% in benign prostatic hyperplasia group and 31.82% in normal control group. Conclusions The FPSA / TPSA ratios in prostate cancer cases are all less than 10%. Therefore, the FPSA / TPSA ratio can be more effective for the diagnosis of prostate cancer. The determination of the ratio of TPSA / TPSA ratio is of considerable clinical significance when the TPSA concentration is less than 20ug / l.