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目的探讨微量喂养对早产儿血清胃泌素(gastrin,GAS)水平的影响及其对早产儿喂养不耐受的治疗作用。方法将42例早产儿分为观察组(有喂养不耐受)22例与对照组(无喂养不耐受)20例,观察组患儿予微量喂养;对照组患儿行常规喂养。两组患儿分别在生后24 h内及7日龄后行血清胃泌素水平的测定,观察两组患儿治疗1周后临床状况改善情况。结果观察组在入院时的血清胃泌素水平较对照组显著减低,治疗7 d后两组血清胃泌素水平无显著差异;观察组在达全量肠内营养时间、恢复至出生体重时间较对照组显著延长(P<0.05,P<0.01),而在住院期间血清总胆红素水平高峰值方面差异无统计学意义(P>0.05)。两组患儿均未发生一例坏死性小肠结肠炎、吸入性肺炎等严重的喂养并发症。结论早产儿血清GAS水平与胃肠功能紊乱的发生关系密切,微量喂养可促进早产儿胃肠道发育成熟。
Objective To investigate the effect of micronutrient on the level of serum gastrin (GAS) in preterm infants and its therapeutic effect on feeding intolerance in premature infants. Methods Forty-two premature infants were divided into observation group (fed intolerance) and control group (no feeding intolerance). Twenty children in the observation group were given micro-feeding. Children in the control group were given routine feeding. Serum gastrin levels were measured within 24 hours and 7 days after birth in both groups, and the improvement of clinical conditions in both groups was observed after one week of treatment. Results The level of serum gastrin in the observation group was significantly lower than that in the control group. There was no significant difference in serum gastrin level between the two groups after 7 days of treatment. The time of full enteral nutrition and recovery to birth weight in the observation group were longer than those in the control group (P <0.05, P <0.01). There was no significant difference in the peak value of serum total bilirubin during hospitalization (P> 0.05). Neither group of children suffered from severe necrotizing enterocolitis, aspiration pneumonia and other serious feeding complications. Conclusions Serum GAS level in preterm infants is closely related to the occurrence of gastrointestinal disorders, and micronutrient feeding can promote the development of gastrointestinal tract in premature infants.