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目的观察急性脑出血患者血清超敏C反应蛋白(hs-CRP)、白介素(IL-6)及高迁移率蛋白-1(HMGB-1)水平的浓度,探讨它们在急性脑出血患者中的变化特点及临床意义。方法选取2013年9月至2014年10月就诊的80例急性脑出血患者和40例健康者作为本研究的对象,按照患者的病情程度分为重症组和轻症组各40例,收集他们入院时、入院后3、5、9 h的血液标本,采用酶联免疫吸附法检测患者HMGB-1以及hs-CRP的含量,比较不同程度病情在不同时间段的HMGB-1以及hs-CRP含量变化。并且根据NIHSS评分评估患者的神经缺损程度。结果与正常对照组比较,重症组患者与轻症组患者的血清TNF-α以及IL-6水平均明显高于正常对照组,差异具有统计学意义(P均<0.01);脑出血患者血清HMGB-1水平以及hs-CRP水平的含量在入院后3、5、9 h均低于入院时(P均<0.05),重症组患者HMGB-1水平以及血清hs-CRP水平在各时段均明显高于轻症组患者,差异具有统计学意义(P均<0.01);脑出血患者NIHSS评分均明显高于正常对照组,差异具有统计学意义(P均<0.01),重症组患者评分高于轻症组(P均<0.01)。结论 HMGB-1以及血清hs-CRP在急性脑出血的发展过程中起着重要作用,对于指导临床进行早期治疗和干预有重要意义。
Objective To observe the levels of serum hs-CRP, IL-6 and HMGB-1 in acute intracerebral hemorrhage (ICH) patients and explore their changes in patients with acute cerebral hemorrhage Characteristics and clinical significance. Methods Eighty patients with acute cerebral hemorrhage and 40 healthy subjects from September 2013 to October 2014 were enrolled in this study. According to the severity of their illness, 40 cases were divided into severe group and mild group, and their admission At 3, 5, and 9 h after admission, the levels of HMGB-1 and hs-CRP in patients were measured by enzyme-linked immunosorbent assay. The changes of HMGB-1 and hs-CRP in different time were compared . And according to NIHSS score to assess the extent of neurological deficit in patients. Results Compared with the normal control group, the levels of serum TNF-α and IL-6 in patients with severe disease and those with mild disease were significantly higher than those in the normal control group (all P <0.01). The levels of serum HMGB 1 levels and hs-CRP levels at 3, 5 and 9 h after admission were significantly lower than those at admission (all P <0.05). HMGB-1 levels and serum hs-CRP levels were significantly higher in all groups The scores of NIHSS in patients with cerebral hemorrhage were significantly higher than those in control group (all P <0.01), those in severe patients were higher than those in patients with mild disease Disease group (all P <0.01). Conclusion HMGB-1 and serum hs-CRP play an important role in the development of acute intracerebral hemorrhage and are of great significance for guiding early treatment and intervention in clinical practice.