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根据Cameron氏1972年提出的建议,肾小球肾炎的治疗措施应抓住清除抗原(病因),改变免疫状态及抑制炎症介质三个环节。阿托品治疗急性肾小球肾炎的机理,乃解除急性肾炎发病时的全身毛细血管和肾小球毛细血管的痉挛,改善肾小球毛细血管内的血液供应,降低肾单位内的血液高凝状态,促使凝聚的红细胞、血小板疏散,减少纤维蛋白在肾小球间质的沉积,阻止新月体的生成和其对毛细血管的压迫,从而达到抗凝、抗血栓形成,并由此抑制炎症介质对肾小球血管的损害,促使由炎症造成的肾单位损伤迅速修复,以恢复肾单位功能。
According to Cameron’s proposal in 1972, the treatment of glomerulonephritis should seize the removal of antigen (etiology), change the immune status and inhibition of inflammatory mediators in three links. Atropine treatment of acute glomerulonephritis mechanism is the lifting of acute nephritis onset of systemic capillaries and glomerular capillary spasm, glomerular capillary to improve blood supply, reduce the nephron blood hypercoagulable state, Promote the aggregation of red blood cells, platelets evacuated, reducing the deposition of fibrin in the glomerular stroma, prevent the formation of the crescent and its capillaries oppression, so as to achieve anticoagulant, antithrombotic, and thus inhibit the inflammatory mediators Glomerular vascular damage, prompted by rapid renal damage caused by inflammation repair unit to restore nephron function.