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在抗生素治疗期间常发生出血和凝血酶原减少,严重疾病、营养不良患者具有发生这些并发症的最大危险性。近年报道,凝血病与包括头孢菌素类在内的N—甲硫四唑(NMTT)有关,最明显的是Moxalactam和头孢孟多。NMTT侧链存在于这些及其它抗生素中(包括头孢哌酮和头孢替坦),干扰依赖维生素K的凝血因子的碳氧化作用。继后的人体研究中,给予含NMTT的抗生素可导致去碳氧凝血酶原和维生素K_(2(?)3)环氧化物升高,提示NMTT侧链可抑制维生素K代谢有关的环氧化物还原酶酶系和凝血因子的激活。然而,在继往的研究中,接受氨基糖苷
Bleeding and prothrombin reduction often occur during antibiotic treatment, and patients with severe diseases and malnutrition have the greatest risk of developing these complications. In recent years, it has been reported that coagulopathy is related to N-methylthioxazole (NMTT), including cephalosporins, most notably Moxalactam and cefadroxone. The NMTT side chains are present in these and other antibiotics, including cefoperazone and cefotetan, and interfere with the carbon oxidation of vitamin K-dependent clotting factors. Subsequent human studies, the administration of NMTT-containing antibiotics led to an increase in desoxyprogesterone and vitamin K 2 (3) epoxide, suggesting that NMTT sidechain inhibits vitamin K metabolism-related epoxides Activation of reductase enzymes and coagulation factors. However, in the previous study, aminoglycosides were accepted