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目的:观察双花解毒颗粒对豚鼠变应性接触性皮炎的抑制作用。方法:10%二硝基氯苯(DNCB)-丙酮溶液涂抹去毛皮肤复制豚鼠变应性接触性皮炎模型,口服给药,通过观察耳廓肿胀度和病理图片,观察药物各剂量组的作用。结果:双花解毒颗粒5个剂量组均显著减小豚鼠耳肿胀度,但无明显量效关系。结论:双花解毒颗粒对豚鼠变应性接触性皮炎有明显抑制作用。
Objective: To observe the inhibitory effect of Shuanghua Jiedu Granule on allergic contact dermatitis in guinea pigs. Methods: DNCB - acetone solution was applied to the dehairing skin to replicate the model of allergic contact dermatitis in guinea pigs. The model was orally administered. The effects of each dosage group were observed by observing the auricular swelling and histopathology. . Results: Five doses of Shuanghua Jiedu Granules significantly reduced the degree of ear swelling in guinea pigs, but no significant dose-effect relationship. Conclusion: Shuanghua Jiedu Granule has obvious inhibitory effect on allergic contact dermatitis in guinea pigs.