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用抗甲状腺药物(ATD)治疗Graves病(GD)存有争议,尤其是关于疗程长短。为了更清楚地确定一个理想的疗程,作者进行了前瞻随机性研究,对照用甲亢平进行了6个月和18个月的治疗。所有患者连续研究40个月以上,94名患者随机分成组_1和组_2两组,分别行6个月和18个月治疗。GD的诊断按常规临床指标。每人行甲状腺扫描,测定TT_3、TT_4、FT_4I,检测HLA A、B、Dr型和甲状腺刺激抗体(TSab)。所有病人在诊断和治疗3个月、6个月和组_2在治疗后12个月和18个月时行体检和激素水平测定。在治疗停止后或发现有
Treatment of Graves’ disease (GD) with antithyroid drugs (ATDs) is controversial, especially with regard to the duration of the treatment. In order to more clearly determine an ideal course of treatment, the authors conducted a prospective randomized study comparing hyperthyroidism with 6 and 18 months of treatment. All patients were studied continuously for more than 40 months. Ninety-four patients were randomly divided into two groups: group 1 and group 2, which were treated for 6 months and 18 months respectively. GD diagnosis according to conventional clinical indicators. Thyroid scans were performed in each patient. TT_3, TT_4 and FT_4I were measured and HLA A, B, Dr and thyroid stimulating antibodies (TSabs) were detected. All patients were tested and treated for 3 months, 6 months and group 2 at 12 and 18 months after treatment, physical examination and hormone levels were measured. After treatment is stopped or found