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目的探讨老年急性白血病的临床特点。方法分析45例老年急性白血病患者的临床资料,包括临床特征、骨髓象、染色体、免疫分型、基础疾病及化疗的缓解率。结果老年急性白血病基础疾病发病率高达73.33%,染色体异常占35.56%,完全缓解率低,仅35.71%。结论老年急性白血病细胞遗传学异常、生理功能减退及合并基础疾病是缓解率低的主要原因,需进一步寻找更有效的治疗策略。
Objective To investigate the clinical features of senile acute leukemia. Methods Clinical data of 45 elderly patients with acute leukemia were analyzed, including clinical features, bone marrow, chromosomes, immunophenotypes, underlying diseases and response rate to chemotherapy. Results The incidence of basic diseases of elderly acute leukemia was as high as 73.33%, chromosomal abnormalities accounted for 35.56%, and the complete remission rate was only 35.71%. Conclusions Cytogenetic abnormalities, hypogonadism and underlying diseases in elderly patients with acute leukemia are the main reasons for the low response rate. It is necessary to find more effective treatment strategies.