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目的了解胃癌患者围手术期的免疫功能变化,探讨其临床意义。方法应用流式细胞仪检测82例胃癌患者手术前后外周血中T细胞2种表面抗原CD69、HLA-DR,并与良性病变患者进行对照。结果发现胃癌患者术前CD69细胞百分率低于对照组(P<0.01),HLA-DR细胞百分率与对照组相近(P>0.05)。术后胃癌患者的CD69、HLA-DR细胞百分率较术前均明显增高(P<0.01)。结论胃癌患者术前免疫功能低下,术后活化T细胞明显增多,表明切除肿瘤有利于提高患者的免疫功能,增强机体的抗癌能力,故应尽量争取根治性切除肿瘤。
Objective To understand the perioperative immune function in patients with gastric cancer and to explore its clinical significance. Methods Flow cytometry was used to detect CD69 and HLA-DR of T cell surface antigen in peripheral blood of 82 patients with gastric cancer before and after surgery. The patients were compared with benign lesions. The results showed that the percentage of preoperative CD69 cells in gastric cancer patients was lower than that in the control group (P <0.01), the percentage of HLA-DR cells was similar to that of the control group (P> 0.05). The percentage of CD69 and HLA-DR cells in patients with postoperative gastric cancer were significantly higher than those before operation (P <0.01). Conclusion The preoperative immune function is low and the number of activated T cells is obviously increased in patients with gastric cancer. It shows that the removal of the tumor is beneficial to improve the immune function and enhance the anti-cancer ability of the patients. Therefore, radical resection of the tumor should be pursued.