论文部分内容阅读
目的探讨同步放化疗治疗局部晚期宫颈癌的疗效和不良反应。方法 80例经病理确诊、临床分期为Ⅱb~Ⅲb期局部晚期宫颈癌患者随机分成两组,每组各40例,均予根治性放疗,体外放疗均采用直线加速器15 MV X射线,DT46~50 Gy,腔内治疗采用192Ir后装机,A点6 Gy/周,总剂量为36~42 Gy。两组放疗方法相同,同步放化疗组在放疗前每周日加用多西紫杉醇(希存)40 mg静滴,共6周。观察近期疗效、3年生存率及放化疗并发症。结果放疗后3个月同步放化疗组有效率(100%)明显高于单纯放疗组72.5%(P<0.05),局部复发率、远处转移率两组分别为5.0%、2.5%和17.5%、15.0%,差异有统计学意义(P<0.05);3年生存率分别为82.5%和55.0%(P<0.05),而毒副作用无明显增加(P>0.05)。结论同步放化疗能提高局部晚期宫颈癌患者的疗效及生存率,降低局部复发率及远处转移率。
Objective To investigate the efficacy and adverse reactions of concurrent chemoradiotherapy in the treatment of locally advanced cervical cancer. Methods Eighty patients with locally advanced cervical cancer with stage Ⅱb ~ Ⅲb were randomly divided into two groups, 40 cases in each group. All patients were treated with radical radiotherapy. Radiotherapy was performed in vitro with linear accelerator 15 MV X - ray and DT46 ~ 50 Gy, after the installation of 192Ir endoscopic treatment, A point 6 Gy / week, the total dose of 36 ~ 42 Gy. The two groups of the same radiotherapy methods, concurrent chemoradiotherapy group plus docetaxel (Greek deposit) 40 mg intravenously every week before radiotherapy for 6 weeks. Observation of short-term efficacy, 3-year survival rate and radiotherapy and chemotherapy complications. Results The efficiency of concurrent chemoradiotherapy (100%) 3 months after radiotherapy was significantly higher than that of radiotherapy alone 72.5% (P <0.05). The rates of local recurrence and distant metastasis were 5.0%, 2.5% and 17.5% (P <0.05). The 3-year survival rates were 82.5% and 55.0% respectively (P <0.05), while the toxic side effects did not increase significantly (P> 0.05). Conclusions Simultaneous chemoradiotherapy can improve the curative effect and survival rate of patients with locally advanced cervical cancer and reduce the local recurrence rate and distant metastasis rate.