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传统认为,组胺在体内主要由肥大细胞和嗜硷性白细胞产生和释放。但近年来许多学者报道,恶性肿瘤组织和患者血液中组胺含量显著高于正常人,并且其组胺含量和肿瘤的转归明显相关,即肿瘤恶化或转移时组胺含量升高,肿瘤缩小或静止时组胺含量降低。进一步研究发现,肿瘤患者体内增高的组胺含量并非肥大细胞或嗜硷性细胞所产生,而是来源于肿瘤细胞。
Traditionally, histamine is mainly produced and released by mast cells and basophils in the body. However, in recent years, many scholars have reported that histamine levels in the blood of malignant tumor tissues and patients were significantly higher than those in normal subjects, and the histamine content was significantly correlated with the prognosis of the tumor, that is, the histamine content was increased and the tumor was reduced Or resting histamine levels decreased. Further study found that tumor patients increased histamine content is not generated by mast cells or basophils, but from tumor cells.