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目的 分析颈淋巴结阴性 (N0 )鼻咽癌放射治疗后颈淋巴结复发的影响因素。方法 采用Logistic回归方法回顾性分析接受放射治疗的N0 期鼻咽癌 2 11例复发因素。结果 2 11例N0 期鼻咽癌放射治疗后 49例复发。采用面颈联合野放射治疗 ,上颈预防剂量 >5 0Gy比面颈分野上颈剂量 5 0Gy者颈淋巴结复发率低 (t=12 .93,P =0 .0 0 0 )。咽旁间隙受侵 ,T分期高 ,颈淋巴结复发率高 (t =14.91,P =0 .0 0 1及t=8.78,P =0 .0 0 3)。全颈预防照射比单纯上颈预防照射的下颈复发率低 (χ2 =3 .0 5 ,P >0 .0 5 )。结论 对于N0 期鼻咽癌应采用面颈联合野放射治疗及全颈预防照射 ,上颈预防量应 >5 0Gy ,以降低颈淋巴结复发率
Objective To analyze the influencing factors of cervical lymph node recurrence after radiotherapy for cervical lymph node-negative (N0) nasopharyngeal carcinoma. Methods Logistic regression was used to analyze the relapse factors of 2 11 cases of nasopharyngeal carcinoma of N0 stage undergoing radiotherapy. Results 21 cases of N0 nasopharyngeal carcinoma recurrence after radiotherapy. With the combination of facial and neck radiotherapy, the rate of upper cervical prophylaxis> 50 Gy was lower than that of cervical and cervical neck (> 50 Gy) in neck and neck lymph node metastasis (t = 12.93, P = 0.0000). Parapharyngeal space invasion, high T stage, cervical lymph node recurrence rate (t = 14.91, P = 0.0001 and t = 8.78, P = 0.003). The rate of neck recurrence was lower in patients with full neck prophylaxis than in those with simple upper neck prophylaxis (χ2 = 3.05, P> 0.05). Conclusion N0 stage nasopharyngeal carcinoma should be combined with face-neck radiotherapy and whole-neck radiation therapy, prevention of upper cervical mass should be> 50 Gy to reduce the recurrence rate of cervical lymph nodes