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MT01是依据人线粒体DNA序列设计的单链寡核苷酸,具有免疫负调节活性。多项研究显示,MT01在抑制由病原体感染所引起的有害、过度的免疫反应以及抑制牙槽骨吸收和促进成骨细胞活化方面有着显著的效果。炎症和骨吸收是牙周疾病的本质。本文就MT01的最新研究进展及其在牙周炎方向的相关研究做一综述。
MT01 is a single-stranded oligonucleotide designed on the basis of human mitochondrial DNA sequence and has immunoregulatory activity. A number of studies have shown that MT01 has a significant effect in inhibiting the deleterious and excessive immune response caused by pathogen infection as well as inhibiting alveolar bone resorption and promoting osteoblast activation. Inflammation and bone resorption are the essence of periodontal disease. This article reviews the recent research progress of MT01 and its related research in periodontitis.