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用大剂量阿糖胞苷与美托散龙(mitoxantrone)联合(简称HAM)治疗40例难治性急性髓细胞白血病。所有病人在此治疗前都接受标准化的第一线药物6-TG、Ara-C和DNR9天的化疗。 HAM化疗方案是:大剂量阿糖胞苷3g/m~2/天,每隔12小时输一次,每次持续3小时,连用4天;美托散龙开始为12mg/m~2/天,每次输30分钟,在第3、4、5天用,以后改为10mg/m~2/天,在第2、3、4、5天用直到第2、3、4、5、6天用。治疗结果有21例CR(53%),1例PR,5例无效。主要副作用是:恶心、呕吐、粘膜炎和腹泻。有1例死
40 patients with refractory acute myeloid leukemia were treated with high dose of cytarabine and mitoxantrone (HAM). All patients received standard chemotherapy first-line drugs 6-TG, Ara-C and DNR 9 days prior to this treatment. HAM chemotherapy is: high-dose cytarabine 3g / m ~ 2 / day, once every 12 hours of lose, each time for 3 hours, once every 4 days; Mito Tuolong began to 12mg / m ~ 2 / day, Each time you lose 30 minutes in the first 3,4,5 days, later changed to 10mg / m ~ 2 / day, in the first 2,3,4,5 days until the first 2,3,4,5,6 days use. Treatment results were 21 cases of CR (53%), 1 case of PR, 5 cases ineffective. The main side effects are: nausea, vomiting, mucositis and diarrhea. 1 case died