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目的:以深圳市宝安区院外心搏骤停（OHCA）真实世界数据为基础，通过分析宝安区自动体外除颤器（AED）实际覆盖情况，探索符合快速发展城市特点的AED配置优化策略。方法:采用回顾性观察性研究方法，连续性纳入2019年3月1日至2020年2月29日深圳市宝安区心搏骤停数据库登记的资料。通过计算每个OHCA事件发生地点与能够获取到的AED之间的最小距离，设定最小距离≤100 m为AED可覆盖，最小距离>100 m为AED不可覆盖，分析公共区域和非公共区域的AED覆盖情况；并分析假设对部分OHCA热点区域各配置1台AED后AED覆盖率的变化。基于目前宝安区公共区域内学校、政府、运动场所、地铁、旅游景点、公园的AED不能满足24 h可随时获取的实际情况，假设公共区域内所有AED均满足24 h可随时获取，分析可随时获取AED对AED覆盖率的影响。结果:最终共纳入525例OHCA事件，OHCA发生率在住宅小区和工业区最高，分别为54.5%（286/525）和14.3%（75/525）。深圳市宝安区现有252台AED，在AED覆盖范围内发生OHCA事件数为115例，即使基于所有AED满足24 h内可随时获取的理想状态，覆盖率也仅为21.9%（115/525）；公共区域与非公共区域AED覆盖率分别为31.6%（37/117）和19.1%（78/408），存在分布不均，非公共区域AED覆盖率偏低。假设对发生2例以上OHCA事件的住宅小区和工业区分别配置1台AED后，非公共区域AED覆盖率则由配置前的19.1%（78/408）提高至28.2%（115/408），可基本满足OHCA事件发生时能随时获取AED。目前宝安区公共区域内部分AED存在24 h不可随时获取的情况，如能达到公共区域内所有AED均满足24 h可随时获取的理想状态，则整体区域AED覆盖率可从16.8%（88/525）提升至21.9%（115/525），公共区域AED覆盖率可从29.1%（34/117）提升至31.6%（37/117），非公共区域AED覆盖率则可从13.2%（54/408）提升至19.1%（78/408）。结论:目前宝安区AED配置分布不均，非公共区域AED覆盖率偏低。针对类似深圳的快速发展城市AED的配置策略应是：在保证AED 24 h可随时获取的前提下，优先覆盖包括住宅小区和工业区在内的非公共区域；在公共区域内应满足24 h可随时获取。“,”Objective:To explore the automated external defibrillator (AED) configuration optimization strategy in line with the characteristics of the rapidly developing cities by analyzing the actual coverage of AED in Bao\'an District based on the real world data of out-of-hospital cardiac arrest (OHCA) in Bao\'an District, Shenzhen City.Methods:The data of cardiac arrest database registered in Bao\'an District of Shenzhen City from March 1, 2019 to February 29, 2020 were included in a retrospective observational study. The AED coverage of public and non-public areas was analyzed by calculating the minimum distance between the occurrence place of each OHCA event and the nearest AED. The minimum distance ≤100 m was set as AED coverage, and the minimum distance > 100 m was set as non-AED coverage. It was assumed that one AED was configured for each OHCA hotspot area, then the AED coverage changes were analyzed. Based on the actual situation that the AED in schools, governments, sports venues, subways, tourist attractions and parks of public areas in Bao\'an District could not be obtained at any time within 24 hours, it was assumed that all AED in the public areas could be obtained at any time within 24 hours, the impact of AED available at any time on AED coverage was analyzed.Results:A total of 525 cases of OHCA were enrolled. The highest incidence of OHCA was found in residential and industrial areas [54.5% (286/525) and 14.3% (75/525), respectively]. There were 252 AED in Bao\'an District, Shenzhen, and 115 OHCA events occurred within the coverage area of AED. Even if all AED met the ideal state that could be obtained at any time within 24 hours, the coverage rate was only 21.9% (115/525). The AED coverage rate of the public areas and non-public areas was 31.6% (37/117) and 19.1% (78/408) respectively, with uneven distribution, and the AED coverage rate of non-public areas was low. Assuming that the residential community and industrial zone with more than 2 OHCA cases were respectively equipped with one AED, the coverage rate of AED in the non-public areas increased from 19.1% (78/408) to 28.2% (115/408), basically meeting the requirement that AED could be obtained at any time when OHCA events occurred. Some AED in the public areas of Bao\'an District were not available at any time within 24 hours. If the ideal state that all AED in the public area could be obtained at any time within 24 hours could be achieved, the AED coverage rate of all regions increased from 16.8% (88/525) to 21.9% (115/525), the AED coverage rate of the public areas increased from 29.1% (34/117) to 31.6% (37/117), the AED coverage rate of the non-public areas increased from 13.2% (54/408) to 19.1% (78/408).Conclusions:AED configuration in Bao\'an District was unevenly distributed, and the coverage rate of AED in non-public areas was low. The allocation strategy for AED in fast-growing cities like Shenzhen should be as follows: on the premise of ensuring AED availability for 24 hours, priority should be given to covering the number of AED in the non-public areas including residential communities and industrial zones; AED is available in the public areas for 24 hours.