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探讨补肾活血方治疗更年期综合征的作用机制。选用雌性SD大鼠“更年期”模型 5 0只 ,随机分配到生理盐水组和各用药组 (补肾活血方低、中、高剂量组 ,乙烯雌酚组 ) ,每组 10只 ,设 10只青年SD大鼠为对照组。观察各组子宫重量指数、阴道上皮脱落细胞检查、血清FSH、LH、E2 的变化。结果 :各用药组均能使更年期鼠子宫重量指数增加 ,其与补肾活血方的剂量呈依赖性增加 (高剂量组P <0 0 5 )。各用药组均能使更年期鼠阴道上皮细胞出现不同程度的角化现象 (补肾活血方中和高剂量组P <0 0 5 )。各用药组均能明显降低更年期鼠血清FSH的含量 (低、中剂量组P <0 0 1,高剂量组P <0 0 0 1) ,有效降低血清LH的含量 (补肾活血方高剂量组P <0 0 0 1) ,提高E2 含量 (中、高剂量组P <0 0 1)。结论 :补肾活血方治疗更年期综合征疗效好 ,其作用机制可能与调节性激素水平有关
To explore the mechanism of Bushen Huoxue Prescription in the treatment of climacteric syndrome. Fivety female rats of “menopause” model were selected and randomly assigned to the normal saline group and each drug group (low, middle and high doses of Bushen Huoxue Fang and ethylene estradiol). Each group had 10 rats and 10 young people were selected. SD rats were the control group. The uterine weight index, vaginal epithelial exfoliative cell examination, serum FSH, LH, and E2 were observed in each group. RESULTS: Each drug group can increase the weight index of the uterus in the climacteric rats, and it has a dose-dependent increase in the dose of Bushen Huoxue Fang (high dose group, P < 0 05). Each drug group can make the vaginal epithelial cells of the menopause appear different degrees of keratinization (Bushen Huoxue Fang and high dose group P <0 05). Each drug group can significantly reduce the serum FSH levels in climacteric rats (low and middle dose group P <0 01, high dose group P <0 0 01), effectively reduce the serum LH content (Bushen Huoxue Fang high dose group P <0 0 0 1), increase E2 content (medium and high dose group P <0 01). Conclusion : Bushen Huoxue Decoction is effective in treating climacteric syndrome, and its mechanism of action may be related to the regulation of sex hormone levels