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目前,全世界估计用于病毒性肝炎的药物已达600种之多。抗肝炎病毒药物,临床应用能抑制乙肝病毒复制的药物至今仅有人干扰素(HIFN-α,β),阿糖腺苷(Ara-A)及单磷酸盐(Ara-AMP)和无环鸟苷(Acyclovir),其它尚在试验阶段。人干扰素按其抗原性不同可分为α,β,γ三个类型。每个类型根据其氨基酸顺序不同又分为几个亚型。α,β,γ三类之间理化性质以及生物学活性有所不同。由于干扰素有种属特异性,使用人类干扰素必须用人细胞制备,目
At present, there are estimated 600 kinds of drugs used for viral hepatitis worldwide. Anti-hepatitis virus drugs, the clinical application of drugs that can inhibit the replication of hepatitis B virus so far only human interferon (HIFN-α, β), Ara-A and monophosphates (Ara-AMP) and acyclovir (Acyclovir), others are still experimental stage. Human interferon according to their antigenicity can be divided into α, β, γ three types. Each type is divided into several subtypes based on their amino acid sequence. α, β, γ three types of physical and chemical properties and biological activity are different. Due to the species-specific nature of interferon, the use of human interferon must be prepared from human cells