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目的了解四川省绵阳市男男性行为者(MSM)梅毒新发感染情况及影响因素。方法 2009年6—9月采用同伴推动招募法(RDS)在绵阳城区招募调查符合条件梅毒检测阴性的MSM建立开放性前瞻队列,每年随访1次,连续3年。随访中不足基线调查样本部分结合滚雪球抽查法,依据纳入条件补充调查对象。结果研究期间共纳入队列583人,随访535.5人年,梅毒阳转30例,新发感染率5.6/100人年(95%CI=3.7/100人年~7.6/100人年),近2年明显下降。多因素分析显示,婚姻状况(RR=2.377,95%CI=1.035~5.459)、艾滋病知识知晓(RR=4.278,95%CI=1.941~9.431),近1年接受过同伴教育(RR=2.281,95%CI=1.081~4.815),近6月诊断过性病(RR=4.743,95%CI=1.829~12.302)是梅毒新发感染的独立影响因素。结论绵阳市MSM人群梅毒新发感染有所下降,但感染率仍较高,受婚姻状况、艾滋病知识知晓、同伴教育和性病感染影响。
Objective To investigate the new onset of syphilis infection and its influencing factors in MSM in Mianyang City of Sichuan Province. Methods From June to September 2009, an open prospective cohort of MSM recruited by peer-driven recruitment (RDS) in Mianyang urban area was selected to investigate. An open prospective cohort of MSM patients with negative syphilis was selected and followed up for 3 consecutive years. Shortage of follow-up baseline survey sample part combined with snowballing checks, according to the conditions to add the survey. Results During the study period, a total of 583 cohorts were enrolled in this study. The follow-up period was 535.5 years. Thirty cases of positive syphilis occurred and the rate of new infections was 5.6 / 100 years (95% CI = 3.7 / 100 to 7.6 / 100 years) Significant decline. Multivariate analysis showed that marital status (RR = 2.377, 95% CI = 1.035-5.459), knowledge of AIDS (RR = 4.278, 95% CI = 1.941-9.431) and peer education in the past year (RR = 95% CI = 1.081 ~ 4.815). STD (RR = 4.743, 95% CI = 1.829 ~ 12.302) was diagnosed in recent 6 months as an independent influencing factor for the new infection of syphilis. Conclusions The incidence of new syphilis infection in MSM population in Mianyang City has declined, but the infection rate is still high. It is affected by marital status, AIDS knowledge, peer education and STD infection.