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随着分子生物学、分子遗传学与分子药理学,特别是药物基因组学的发展,人们逐渐认识到,不同个体对同一药物的不同反应,大多源于基因的差异。由此,在遗传药理学的基础上,发展形成了药物基因组学这一新学科,以分子和基因水平上的研究揭示个体对药物不同反应的机制,为科学合理用药开拓了新的思路和途径。现就慢性阻塞性肺疾病患者常用药物的药物基因组学与个体化治疗进行综述。
With the development of molecular biology, molecular genetics and molecular pharmacology, especially pharmacogenomics, people gradually come to realize that the different responses of different individuals to the same drug mostly come from the differences of genes. Thus, on the basis of genetic pharmacology, the development of the formation of a new discipline of pharmacogenomics, molecular and gene level studies reveal the mechanism of individual reactions to different drugs, scientific and rational use of drugs to open up new ideas and ways . Now on the patients with chronic obstructive pulmonary disease drug genomics and individualized treatment are reviewed.