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目的:检测贲门癌高发区人群慢性萎缩性贲门炎(CAG)患者血清蛋白质质谱变化。方法:采用弱阳离子结合芯片(WCX2)及表面加强激光解吸/电离飞行时间质谱仪(SELDI-TOF-MS)对食管癌高发区普查人群中活检组织诊断为正常的63人和CAG的57人的血清蛋白质质谱进行检测,找出差异蛋白质。结果:2组间有165种质核比在2010~49170的蛋白质谱图被标记,其中CAG人群中升高37种,降低31种(P<0.05)。结论:CAG人群存在多种血清蛋白质的变化。
Objective: To detect the changes of serum protein and protein in patients with chronic atrophic cardialitis (CAG) in high incidence area of cardia cancer. Methods: Sixty-three patients with normal biopsies and 57 patients with CAG in the general population of esophageal cancer were studied by WCX2 and SELDI-TOF-MS. Serum protein mass spectrometry was performed to find out the differential proteins. Results: A total of 165 proteins in the two groups were labeled in 2010 ~ 49170, among which 37 were elevated in CAG and 31 were decreased (P <0.05). Conclusion: There are many serum protein changes in CAG population.