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目的:观察羧甲淀粉钠溶液对反复呼吸道感染(RRI)儿童外周血T淋巴细胞亚群的影响及疗效。方法:RRI患儿68例,随机分为观察组(35例)与对照组(33例)。两组患儿均予抗感染、抗病毒、退热和止咳化痰等综合性治疗。观察组患儿在此基础上口服羧甲淀粉钠溶液,连用6个月。比较两组患儿治疗前后外周血T淋巴细胞亚群的变化,并进行临床疗效和不良反应的观察。结果:治疗6个月后,观察组患儿外周血CD_4~+水平和CD_4~+/CD_8~+比值均较治疗前明显上升,CD_8~+水平较治疗前明显下降(P<0.05或0.01),而对照组治疗前后CD_4~+、CD_8~+水平和CD_4~+/CD_8~+比值无明显变化(P>0.05)。观察组疗效(91.43%)明显优于对照组(66.67%),差异有统计学意义(P<0.05)。两组治疗期间均无明显不良反应发生。结论:羧甲淀粉钠可纠正儿童RRI外周血T淋巴细胞亚群功能紊乱,改善患儿的细胞免疫失衡状态,治疗儿童RRI疗效确切,安全性好。
Objective: To observe the effect of sodium carboxymethyl starch solution on T lymphocyte subsets in children with recurrent respiratory tract infection (RRI) and its therapeutic effect. Methods: 68 children with RRI were randomly divided into observation group (35 cases) and control group (33 cases). Two groups of children were anti-infective, anti-virus, antipyretic and cough and phlegm and other comprehensive treatment. Observation group of children on the basis of oral sodium carboxymethyl starch solution, once every 6 months. The changes of T lymphocyte subsets in peripheral blood before and after treatment in both groups were compared and clinical efficacy and adverse reactions were observed. Results: After 6 months of treatment, the levels of CD_4 ~ + and CD_4 ~ + / CD_8 ~ + in the peripheral blood of the observation group were significantly higher than those before treatment, and the levels of CD_8 ~ + in the observation group were significantly lower than those before treatment (P <0.05 or 0.01) , While there was no significant difference in the levels of CD 4 +, CD 8 + and CD 4 + / CD 8 + before and after treatment in the control group (P 0.05). The observation group (91.43%) was significantly better than the control group (66.67%), the difference was statistically significant (P <0.05). No significant adverse reactions occurred during treatment in both groups. CONCLUSION: Sodium carboxymethyl starch can correct the disorder of T lymphocyte subsets in peripheral blood of children with RRI, and improve the cellular immune imbalance in children. The treatment of children with RRI has definite curative effect and good safety.