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目的研究联合应用维A酸和亚砷酸治疗急性早幼粒细胞白血病(APL)的效果。方法随机将初发的APL患者分为两组,分别给予维A酸和维A酸+亚砷酸,判别疗效及毒副作用。结果联合应用维A酸+亚砷酸治疗APL疗效较好,缩短住院时间,死亡率明显降低,但药物毒副作用较大。结论联合应用维A酸+亚砷酸诱导缓解APL疗效较好,值得临床推广应用。
Objective To study the effect of combination of retinoic acid and arsenious acid in the treatment of acute promyelocytic leukemia (APL). Methods The newly diagnosed APL patients were randomly divided into two groups, treated with tretinoin and tretinoin + arsenite respectively, and the curative effect and side effects were evaluated. Results The combined application of Tretinoin + arsenious acid was effective in treating APL, shortening the length of stay in hospital and significantly reducing the mortality rate, but the side effect of the drug was larger. Conclusions The combination of Victoria A acid + arsenic acid induced remission of APL better effect, worthy of clinical application.