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目的探讨美托洛尔联合硝酸甘油治疗冠心病心绞痛对血清TNF-α、BNP、IL-18水平的影响。方法冠心病心绞痛患者随机分为观察组和对照组各102例。在常规治疗和护理的基础上给予观察组美托洛尔联合硝酸甘油治疗,对照组仅给予硝酸甘油治疗,并于治疗前后检测2组患者血清肿瘤坏死因子-α(TNF-α)、心房脑钠肽(BNP)、白介素-18(IL-18)水平,比较其差异性。结果治疗前2组TNF-α、BNP、IL-18水平差异无统计学意义(P>0.05)。治疗后2组血清各指标均有不同程度下降,且观察组降幅大于对照组,差异均有统计学意义(P<0.05)。结论美托洛尔联合硝酸甘油治疗冠心病心绞痛后可显著降低血清TNF-α、BNP及IL-18水平。
Objective To investigate the effects of metoprolol combined with nitroglycerin on the serum levels of TNF-α, BNP and IL-18 in patients with coronary heart disease and angina pectoris. Methods Coronary angina patients were randomly divided into observation group and control group of 102 cases. Metoprolol combined with nitroglycerin was given to the observation group on the basis of routine treatment and nursing. Only nitroglycerin was given to the control group. Serum tumor necrosis factor-α (TNF-α) and atrial natriuretic peptide (BNP), interleukin-18 (IL-18) levels, the differences were compared. Results There was no significant difference in the levels of TNF-α, BNP and IL-18 between the two groups before treatment (P> 0.05). After treatment, the indexes of serum in 2 groups decreased to some extent, and the decrease in observation group was larger than that in control group (P <0.05). Conclusion Metoprolol combined with nitroglycerin can significantly reduce the serum levels of TNF-α, BNP and IL-18 after treatment of angina pectoris.