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目的探讨患有高胆红素血症的新生儿体内IgA、IgG、IgM以及补体C3、C4水平变化的临床意义。方法收集2013年2月至2015年2月衡水市人民医院新生儿科收治的高胆红素血症患儿155例为研究对象,按参考标准分为轻度高胆组(n=78)、中度高胆组(n=45)、重度高胆组(n=32);同时选择胆红素水平正常的新生儿123例作为正常对照组,对所有病例的胎龄、日龄、体重、胆红素检测水平进行统计,对IgA、IgG、IgM、补体C3、C4水平进行检测。结果随着黄疸进行性加重,IgA和IgM逐渐降低,各组间差异均有统计学意义(P<0.05),IgG各组间差异无统计学意义(P>0.05),C3、C4轻度高胆组和中度高胆组与正常对照组比较差异有统计学意义(P<0.05),而C3、C4重度高胆组和正常对照组比较差异无统计学意义(P>0.05)。结论高胆红素血症对新生儿体液免疫有影响,降低其免疫力,应加强对新生儿胆红素的监测,及时采取有效措施控制其发展。
Objective To investigate the clinical significance of IgA, IgG, IgM and C3, C4 levels in newborns with hyperbilirubinemia. Methods A total of 155 children with hyperbilirubinaemia admitted to Department of Neonatology, Hengshui People’s Hospital from February 2013 to February 2015 were enrolled in this study. The patients were divided into mild hyperbilirubinemia group (n = 78) (N = 45) and severe hypercholesterolemia group (n = 32). Meanwhile, 123 newborns with normal bilirubin level were selected as the normal control group. The gestational age, age, body weight, Statistical analysis of the level of red pigment, IgA, IgG, IgM, complement C3, C4 levels were detected. Results As the jaundice progressed, the levels of IgA and IgM gradually decreased, the differences among the groups were statistically significant (P <0.05). There was no significant difference between the groups of IgG (P> 0.05) There were significant differences between the gall bladder group and the moderate high gall bladder group and the normal control group (P <0.05), while there was no significant difference between the C3 and C4 severe high gall bladder group and the normal control group (P> 0.05). Conclusions Hyperbilirubinemia may have an impact on the humoral immunity of neonates and reduce their immunity. The monitoring of neonatal bilirubin should be strengthened and effective measures should be taken to control its development.