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绝经后长期激素治疗的受益和风险不仅决定于患者的选择、用药时机、还与所用激素的制剂、剂量、用药途径有关。尤其是孕激素种类很多,对各靶器官的作用有差别。本文比较了临床上常用的4种孕激素制剂的基础医学资料;介绍近年来对代谢、心血管系统、乳腺癌影响的相关研究结果及国际绝经协会的推荐意见。
The benefits and risks of long-term hormone therapy after menopause not only depend on the choice of patient, the timing of the medication, but also on the formulation, dosage and route of administration of the hormone used. In particular, many types of progesterone, the role of different target organs are different. This article compares the basic medical information of four kinds of progestin preparations commonly used clinically, introduces the related research results of metabolism, cardiovascular system and breast cancer in recent years and the recommendation of International Association of Menopause.