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T细胞是机体内具有重要的免疫调节和效应功能的细胞群体,其功能表达不仅依赖于抗原或促分裂素引起的激活过程,还与细胞增殖有密切关系。基于机体在微生物病原感染时T细胞常处在体温升高与抗原激活影响下,以及升温对肿瘤的生长有抑制作用,本实验研究升温(热休克)对人T淋巴细胞增殖的影响。若以未经热休克预处理的激活淋巴细胞的~3H-胸腺嘧啶核苷(~3H-TdR)在酸不溶性物质(DNA)中的平均参入率为100％,则在先经16～24hPHA活化培养的淋巴细胞进行45℃10min处理后,~3H-
T cells are cell populations with important immunoregulatory and effector functions in the body. Their functional expression depends not only on the activation process induced by antigens or mitogens, but also has a close relationship with cell proliferation. Based on the body’s T lymphocytes in the infection of microbial pathogens often under the influence of elevated body temperature and antigen activation, and temperature rise inhibits the growth of tumors, this study was to study the effect of warming (heat shock) on the proliferation of human T lymphocytes. If the average incorporation rate of ~3H-thymidine (~3H-TdR) in acid-insoluble substances (DNA) of activated lymphocytes that have not been pretreated with heat shock is 100%, they are first activated by 16-24 hPHA. After cultured lymphocytes were treated at 45°C for 10 min, ~3H-