论文部分内容阅读
内源性阿片样物质(Opioid likesubstances,OLS)是神经内分泌系统的重要调节物质,对机体多种生物功能具有调节作用,如疼痛、心血管效应、胃肠功能等。近年人们发现OLS对免疫功能也具有调节活性。一个非常明显的现象是阿片成瘾者较正常人更易罹患病毒性肝炎、肺炎、心内膜炎、菌血症、蜂窝织炎、注射部位化脓感染及其它感染性疾病。进一步检查这些人血中淋巴细胞的数目、功能和丙种球蛋白的水平都有改变。由此提示神经内分泌系统与免疫系统间有某种内在的联系,揭示这些现象的生物学机制无疑对加深认识神经内分泌系统与免疫系统间的相互作用关系以及免疫功能紊乱的临床治疗都具有重要意义。
Opioid likesubstances (OLS) are important regulators of the neuroendocrine system and regulate many biological functions of the body such as pain, cardiovascular effects and gastrointestinal functions. In recent years, people have found OLS also has regulatory activity of immune function. A very obvious phenomenon is that opiate addicts are more susceptible to viral hepatitis, pneumonia, endocarditis, bacteremia, cellulitis, suppurative infection at the injection site and other infectious diseases than normal people. Further examination of these human blood lymphocytes in the number, function and gamma globulin levels have changed. This suggests that the neuroendocrine system and the immune system have some intrinsic relationship between revealing the biological mechanism of these phenomena will undoubtedly deepen the understanding of the relationship between neuroendocrine system and the immune system and the clinical treatment of immune dysfunction are of great significance .