论文部分内容阅读
环氧化酶是花生四烯酸代谢中的一种限速酶,其中的同工酶之一的环氧合酶-2,通过多种途径与诸多肿瘤的发生、发展和预后密切相关.食管癌具有高发病率和死亡率,近年来认为环氧合酶-2通过异型生物质(xenobiotic)代谢,抑制凋亡,参与慢性炎症、免疫抑制,上调血管生成因子的表达,以及促进肿瘤的浸润和转移在其致癌中起重要作用.实验证据表明利用选择性环氧合酶-2抑制剂抑制环氧合酶-2活性可以预防各种组织中肿瘤的形成,包括食管癌.本文就环氧合酶-2对食管癌的致癌作用及选择性环氧合酶-2抑制剂的预防和/或治疗作用作一综述.
Cyclooxygenase is a rate-limiting enzyme in the metabolism of arachidonic acid, and one of the isozymes, cyclooxygenase-2, is closely related to the occurrence, development and prognosis of many tumors through a variety of pathways. Cancer has a high morbidity and mortality. In recent years, it has been suggested that cyclooxygenase-2 is metabolized by xenobiotic, inhibits apoptosis, participates in chronic inflammation, immunosuppression, up-regulates the expression of angiogenic factors and promotes tumor invasion And metastasis play an important role in its carcinogenesis.Experimental evidence that the use of selective cyclooxygenase-2 inhibitors inhibit cyclooxygenase-2 activity can prevent the formation of various tissues of tumors, including esophageal cancer.In this paper, epoxy Synthase-2 on carcinogenesis of esophageal cancer and selective cyclooxygenase-2 inhibitors for the prevention and / or treatment of role.