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目的寻找治疗椎－基底动脉短暂缺血性眩晕（Ｖｅｒｔｅｂｒｏｂａｓｉｌａｒ ｔｒａｎｓｉｅｎｔ ｉｓｃｈｅｍｉｃ ｖｅｒｔｉｇｏ，ＶＢＴＩＶ）的有效药物，为金纳多（ＧＩＮＡＴＯＮ）治疗ＶＢＴＩＶ的临床应用提供客观依据。方法给３３例临床诊断ＶＢＴＩＶ的患者静脉滴注金纳多１０天，每天１０５ｍｇ，治疗前与治疗后（静脉滴注金纳多１０天）同一患者分别行高刺激率ＡＢＲ测试，且为客观对照，在治疗前后分别行扭颈下脑血流图及经颅多普勒（ＴＣＤ）检查。结果ＶＢＴＩＶ患者经用金纳多静脉滴注治疗１０天后高刺激率ＡＢＲ测试５１～１１次／秒Ｖ波潜伏期及Ⅰ～Ⅲ间期、Ⅲ～Ⅴ间期、Ⅰ～Ⅴ间期明显缩短，异常出现率明显减少；治疗后扭颈下脑血流图的阳性率与治疗前相比由４６％降至１２％，ＴＣＤ检测椎基底动脉系统其血流速度等参数在治疗后有不同程度改善。结论高刺激率ＡＢＲ可作为金纳多治疗ＶＢＴＩＶ疗效评估的一个客观指标，金纳多可有效改善ＶＢＴＩＶ患者的内耳微循环，是治疗ＶＢＴＩＶ的有效药物，值得临床推广应用。
Objective To find effective drugs for treating vertebrobasilar transient ischemic vertigo (VBTIV) and provide an objective basis for the clinical application of GINATON in the treatment of VBTIV. Methods 33 patients with clinical diagnosis of VBTIV were given intravenous infusion of Ginaton for 10 days, 105 mg daily. The same patient with high stimulation before and after treatment (intravenous infusion of Ginaton for 10 days) , Respectively, before and after treatment of twisting neck cerebral blood flow diagram and transcranial Doppler (TCD) examination. Results In VBTIV patients, the latency of V wave of 51 ~ 11 beats / second and the interictal Ⅰ ~ Ⅲ, Ⅲ ~ Ⅴinterval, ABV Ⅰ ~ Ⅴ interval were significantly shortened and abnormal after 10 days of treatment with Jinnao intravenous infusion The incidence rate decreased significantly; after treatment, the positive rate of hemilauco-cerebral hemorrhage curve decreased from 46% to 12% before treatment. The blood flow velocity and other parameters of vertebrobasilar artery system by TCD were improved to some extent after treatment. Conclusions High stimulation rate ABR can be taken as an objective indicator of the efficacy of Ginaton in treating VBTIV. Ginaton can effectively improve microcirculation of the inner ear of patients with VBTIV. It is an effective drug for the treatment of VBTIV and is worthy of clinical application.