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早在90多年以前已有人发现晚期乳癌的病人,有的在切除卵巢以后病情可有显著好转,此后,内分泌治疗便成为治疗乳癌的一种有用的手段。但长期使用之后又发现,无论采用何种内分泌疗法,大体上都只有20％-40％的病人能有疗效。医学上把这类内分泌治疗有效的肿瘤称之为激素依赖性肿瘤,无效的称为非激素依赖性肿瘤。显而易见,要判断一个肿瘤是否属于激素依赖性,如用观察疗效的方式,总是只能做“事后诸葛亮”。要是无效,患者的病情便会继续进展,显然知之过晚了。
As early as 90 years ago, some patients with advanced breast cancer have been found, and some may have a significant improvement after ovariectomy. Since then, endocrine therapy has become a useful treatment for breast cancer. However, after long-term use, it was found that no matter what type of endocrine therapy is used, only about 20% to 40% of the patients are generally effective. This kind of endocrine-effective tumors is called hormone-dependent tumors in medicine, which is called non-hormone-dependent tumors. Obviously, to determine whether a tumor is hormone-dependent, such as the way to observe the efficacy, always can only do “hindsight.” If invalid, the patient’s condition will continue to progress, apparently know too late.