论文部分内容阅读
注射用氨苄西林钠是目前临床上广泛使用的广谱抗生素,目前中国药典采用咪唑法测定含量,但操作繁琐、费时、影响因素多。本文参考文献用硝酸汞电位法测定氨苄西林钠原料的方法,测定了8批注射用氨苄西林钠的含量,该法的突出优点是无需对照品,而直接根据消耗的硝酸汞滴定液的摩尔数,按化学当量计算氨苄西林钠的含量,方法简单,结果精密度好。 1 仪器与试药 BP—40半自动青霉素电位滴定分析仪(北京培特新技术有限公司)、铂电极、汞—硫酸亚汞电极。注射用氨苄西林钠(山东齐鲁制药厂、华北制药股份有限公司等生产)。氯化钠为基准物,其他试剂均为分析纯。缓冲液、标准液的配制与标定按中国药典
Ampicillin sodium for injection is widely used in clinical broad-spectrum antibiotics, the current Chinese Pharmacopoeia using imidazole method for the determination of content, but the cumbersome operation, time-consuming, many influencing factors. This article references mercury nitrate potential method for the determination of ampicillin sodium raw materials, determination of the eight batches of ampicillin sodium for injection, the outstanding merit of this method is without reference substance, but directly according to consumption of mercury nitrate titrant molar number , According to the chemical equivalent of ampicillin sodium content, the method is simple, the results of good precision. 1 instruments and reagents BP-40 semi-automatic penicillin potentiometric titrator (Beijing Peite New Technology Co., Ltd.), platinum electrodes, mercuric chloride-mercury electrode. Ampicillin sodium for injection (Shandong Qilu Pharmaceutical Factory, North China Pharmaceutical Co., Ltd. and other production). Sodium chloride as a reference, other reagents were of analytical grade. Buffer, standard solution preparation and calibration according to the Chinese Pharmacopoeia