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目的 从分子生物学方面探讨养胃散的治疗机制 ,测定用药后胃肠黏膜中前列腺素 (PG)、生长抑素 (SS)的变化规律。方法 SD大白鼠为实验动物 ,以消炎痛损伤胃黏膜后 ,再给予中药养胃散 10d ,用放射免疫法测定胃、肠黏膜中的PG及SS的变化。结果 养胃散能明显增加消炎痛损伤后胃肠黏膜中的PG(2 49 42pg/ml)及SS(2 0 2 0pg/ml)的含量 ,与消炎痛组相比差异有显著性 (P <0 .0 1)。结论 中药养胃散能增加胃肠黏膜内PG及SS的分泌 ,是其增强胃黏膜屏障功能的机制之一。
Objective To explore the therapeutic mechanism of Yangweisan from the perspective of molecular biology and to determine the changes of prostaglandin (PG) and somatostatin (SS) in the gastrointestinal mucosa after administration. Methods SD rats were used as experimental animals. After inhalation of gastric mucosa with indomethacin, the rats were given Weiweisan for 10 days. The changes of PG and SS in gastric and intestinal mucosa were measured by radioimmunoassay. Results Yang Wei San could significantly increase the content of PG (2 49 42 pg/ml) and SS (20 0 pg/ml) in gastrointestinal mucosa after innominal injury, and there was significant difference compared with indomethacin group (P < 0 .0 1). Conclusion Traditional Chinese medicine Yang Wei San can increase the secretion of PG and SS in the gastrointestinal mucosa, which is one of the mechanisms that enhance gastric mucosal barrier function.