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目的:探讨人乳头状瘤病毒(Human papillomavirus,HPV)多重感染与新疆维吾尔族妇女宫颈癌的关系。方法:采用导流杂交基因芯片技术对350例新疆维吾尔族宫颈癌患者(宫颈癌组)及100例正常妇女(对照组)宫颈组织中HPV的21种亚型进行检测。结果:350例宫颈癌组织中HPV阳性者291例(包括单一感染及多重感染),阳性率为83.14%。其中HPV单一感染者255例,占宫颈癌患者的72.86%,占HPV阳性宫颈癌的87.63%;而多重感染者36例,占宫颈癌患者的10.29%,占HPV阳性宫颈癌的12.37%。HPV的多重感染中以二重感染为主,占多重感染的91.67%,多重感染的类型以HPV16为主,占多重感染的97.22%。对照组中HPV阳性率为7.00%,其中单一感染者6例,二重感染者1例。两组多重感染率宫颈癌组明显高于对照组,差异有统计学意义(P<0.01)。HPV多重感染在各病理类型的宫颈癌中的分布比例差异无显著性(P>0.05)。HPV多重感染在Ⅰ～Ⅱ期及Ⅲ～Ⅳ期中的分布比例差异无统计学意义。结论:新疆维吾尔族宫颈癌多重感染的类型以HPV16感染为主,多重感染与宫颈癌的病理类型及临床期别无关;多重感染中以二重感染为主,即HPV16与其他类型合并感染,但多重感染的比例较低,类型较单一,这可能与此民族基本居住在新疆,移动较少、与其他民族同婚极少、遗传背景、生活习惯及居住环境等因素有关。
Objective: To investigate the relationship between multiple human papillomavirus (HPV) infection and cervical cancer in Uighur women in Xinjiang. METHODS: Twenty-one subtypes of HPV in cervical tissues of 350 Uygur patients with cervical cancer (cervical cancer group) and 100 normal women (control group) were detected by flow-through hybridization gene chip technique. Results: There were 291 HPV positive cases (including single infection and multiple infection) in 350 cases of cervical cancer, the positive rate was 83.14%. Among them, 255 cases of single infection of HPV accounted for 72.86% of patients with cervical cancer, accounting for 87.63% of HPV-positive cervical cancer; while 36 cases of multiple infections accounted for 10.29% of patients with cervical cancer, accounting for 12.37% of HPV-positive cervical cancer. The multiple infections of HPV were mainly double infections, accounting for 91.67% of multiple infections. The types of multiple infections were HPV16, accounting for 97.22% of multiple infections. The positive rate of HPV in the control group was 7.00%, of which 6 were single infection and 1 was double infection. Two groups of multiple infection rate of cervical cancer was significantly higher than the control group, the difference was statistically significant (P <0.01). There was no significant difference in the distribution of HPV in multiple pathological types of cervical cancer (P> 0.05). There was no significant difference in the distribution of HPV multiple infections between stage Ⅰ ~ Ⅱ and stage Ⅲ ~ Ⅳ. CONCLUSION: HPV16 infection is the most common type of cervical cancer among Uygur nationalities in Xinjiang. Multiple infection is not related to the pathological type and clinical stage of cervical cancer. Infection of multiple infections is mainly of double infection, ie, HPV16 is associated with other types of infection, The proportion of multiple infections is lower and the type is rather single. This may be related to the basic living of the ethnic group in Xinjiang, less movement, less marriage with other ethnic groups, genetic background, living habits and living environment.