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目的评价甘精胰岛素治疗初诊2型糖尿病(T2DM)患者的降糖效果及对胰岛功能的影响。方法初诊T2DM患者80例,随机分为治疗组(甘精胰岛素联合二甲双胍)和对照组(格列美脲联合二甲双胍),治疗12周。结果治疗后两组FBG(空腹血糖)、2 h BG(餐后2 h血糖)、HbAlc(糖化血红蛋白)较治疗前显著下降(P<0.05);治疗组FC-P(空腹C-肽)及2 h C-P(餐后2 h C-肽)显著高于对照组(P<0.05),低血糖发生次数显著低于对照组(P<0.05)。结论甘精胰岛素联合口服药物能有效降低血糖,促进胰岛β细胞功能修复,低血糖发生少率低为初诊T2DM患者有效的降糖方案。
Objective To evaluate the hypoglycemic effect of insulin glargine in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and its effect on islet function. Methods 80 newly diagnosed T2DM patients were randomly divided into treatment group (glargine plus metformin) and control group (glimepiride plus metformin) for 12 weeks. Results After treatment, FBG (fasting blood glucose), 2 h BG (2 h postprandial blood glucose) and HbAlc (glycosylated hemoglobin) decreased significantly in both groups (P <0.05) 2 h CP (2 h postprandial C-peptide) was significantly higher than the control group (P <0.05), the incidence of hypoglycemia was significantly lower than the control group (P <0.05). Conclusion Glargine combined with oral drugs can effectively reduce blood glucose and promote the function of pancreatic β-cell repair, low incidence of hypoglycemia low rate of early diagnosis of T2DM effective hypoglycemic regimen.