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真核细胞起始因子-4E(eIF-4E)是mRNA帽结合磷蛋白,是帽依赖性mRNA翻译过程中的限速因子;同时与真核细胞mRNA的转运和降解关系密切。有研究表明,eIF-4E通过上调某些肿瘤相关蛋白的表达,在多种恶性肿瘤的发生和发展过程中发挥重要作用。
Eukaryotic initiation factor-4E (eIF-4E) is a mRNA-capped phosphoprotein that is a rate-limiting factor in cap-dependent mRNA translation and is closely related to the transport and degradation of eukaryotic mRNA. Studies have shown that eIF-4E plays an important role in the occurrence and development of many malignancies by up-regulating the expression of certain tumor-associated proteins.