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目的研究番泻叶对脾虚泄泻小鼠血常规的影响,为临床选择性的用药提供依据。方法用番泻叶水煎剂灌胃小鼠建立脾虚泄泻模型,正常组小鼠灌胃等量无菌水,造模成功后眼球采血,用CA-500血液自动分析仪进行检测。结果脾虚泄泻小鼠血小板数量及血小板比积显著低于正常组(P<0.01),白细胞、红细胞和血红蛋白与正常组比较没有差异性(P>0.05)。结论番泻叶能降低小鼠的血小板数量,对其他血液指标没有影响。
Objective To study the effect of senna on blood routine in mice with spleen-deficiency diarrhea and to provide basis for clinical selective medication. Methods The spleen deficiency diarrhea model was established by intragastric administration of senna decoction. The mice in normal group were given the same amount of sterile water and the eyeballs were collected after successful modeling. CA-500 automatic blood analyzer was used to detect the diarrhea model. Results The number of platelets and the ratio of platelet in mice with spleen-deficiency diarrhea were significantly lower than those in the normal group (P <0.01). There were no significant differences in leucocyte, erythrocyte and hemoglobin between the two groups (P> 0.05). Conclusions Senna can reduce the number of platelets in mice, but have no effect on other blood indexes.