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目的探讨孕前半年父亲环境危险因素暴露与子代先天性心脏病的病因学关联,为CHD的预防提供依据。方法采用统一制定的调查表,按1:2进行匹配,对先心病例组和对照组的父母分别进行面对面结构式访谈,调查相关的影响因素。结果孕前半年父亲铅暴露(OR=4.516)、母亲自然流产史(OR=5.656)、孕前和孕早期夫妻经常争吵(OR=3.557)与子代CHD的发生存在显著相关性(P<0.05)。结论父亲的职业环境和母亲的精神因素应给予高度关注,积极寻找自然流产史夫妇的高危因素,对预防子代CHD的发生尤为重要。
Objective To explore the etiological relationship between environmental risk factors of father and congenital heart disease of offspring in the first half of pregnancy so as to provide basis for the prevention of CHD. Methods A uniform questionnaire was used to match with 1: 2. The parents of the case-control group and the control group were interviewed face-to-face, and the related factors were investigated. Results There was a significant correlation between father lead exposure (OR = 4.516), mother spontaneous abortion history (OR = 5.656), frequent marital quarrels (OR = 3.557) and CHD occurrence in offspring in the first half of pregnancy (P <0.05). Conclusion The father’s occupational environment and mother’s psychiatric factors should be given high attention. Actively looking for the risk factors of spontaneous abortion couples is especially important in preventing the occurrence of CHD in offspring.