Ⅰ、快速眼球运动与分离性眼震自从19世纪末核间性眼肌麻痹综合征首次被认识以来,内侧纵束(MLF)在眼球运动中的作用已有广泛研究.此综合征表现为MLF损伤侧眼内收障碍,对侧眼外展有分离性眼震(MLF眼震).尽管积累了大量临床资料,但MLF在产生不同形式的眼球运动中的确切作用仍不清楚.近来动物研究提示MLF不仅对水平眼球运动有重要关系,且对垂直眼球运动的产生也有作用.另外MLF参与产生垂直前 I. Rapid Eye Movement and Separation Nocturia The role of the medial longitudinal bundle (MLF) in eye movements has been extensively studied since the end of the 19th century when the interocular ophthalmoplegia syndrome was first recognized. This syndrome is characterized by MLF injury Lateral eye adduction disorder, contralateral ocular delamination with nystagmus (MLF nystagmus) .Although the accumulation of a large number of clinical data, but the MLF in the production of different forms of eye movement exact role remains unclear. Recent animal studies suggest MLF is not only important for horizontal eye movements, but also for vertical eye movements. In addition, MLF is involved in the generation of vertical