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Gold和Freedman(1965)报告,结肠癌含有一种抗原,此种抗原是正常成人肠粘膜所没有的,但存在于原始内胚层,称为消化系统的癌胚抗原(CEA)。此种物质最初是借结肠癌提取物免疫家兔、经正常组织(取自各别肿瘤患者)吸收的抗血清与人体肿瘤提取物的琼脂凝胶双扩散试验加以鉴定的。这种经吸收的抗血清与肿瘤提取物间出现沉淀弧,但与正常成人组织提取物并无反应。其他研究者也曾获得类似的结果。覆盖CEA的红细胞,可为正
Gold and Freedman (1965) reported that colon cancer contains an antigen that is absent from normal adult intestinal mucosa, but is present in the primitive endoderm, the carcinoembryonic antigen (CEA) called the digestive system. This substance was originally identified by an agar gel double diffusion test in which rabbits were immunized with colon cancer extracts, antisera taken from normal tissues (taken from individual tumor patients) and human tumor extracts. This precipitated arc appeared between the absorbed antiserum and the tumor extract but did not respond to normal adult tissue extracts. Other researchers have also obtained similar results. Red blood cells covering CEA can be positive