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目的:探讨前列腺癌组织中雄激素受体(AR)、胰岛素样生长因子1受体(IGF-1R)的蛋白表达并与前列腺癌危险因素进行比较分析。方法:42例前列腺癌根据临床分期、Gleason评分、血清PSA浓度分为中低危组、高危组,采用免疫组织化学方法检测前列腺癌组织中AR及IGF-1R的蛋白表达阳性率,分析这两种蛋白表达阳性率在中低危组、高危组之间的差异。结果:临床分期中低危组、高危组AR表达阳性率分别为57%、66%,两组比较差异无统计学意义(P>0.05);IGF-1R表达阳性率分别为24%、37%,两组比较差异有统计学意义(P<0.05)。Gleason评分中低危组、高危组AR表达阳性率分别为46%、57%,两组比较差异有统计学意义(P<0.05);IGF-1R表达阳性率分别为26%、34%,两组比较差异无统计学意义(P>0.05)。血清PSA浓度中低危组、高危组AR表达阳性率分别为46%、54%,IGF-1R表达阳性率分别为28%、31%,两组比较差异均无统计学意义(P>0.05)。结论:前列腺癌组织中AR蛋白表达在高危Gleason评分时增加,IGF-1R蛋白表达在高危临床分期时增加。
Objective: To investigate the expression of androgen receptor (AR) and insulin-like growth factor 1 receptor (IGF-1R) in prostate cancer tissues and to compare with the risk factors of prostate cancer. Methods: 42 cases of prostate cancer were divided into low-risk group and high-risk group according to clinical stage, Gleason score and serum PSA concentration. Immunohistochemistry was used to detect the positive expression of AR and IGF-1R in prostate cancer tissues. The positive rate of protein expression in low-risk group, high-risk group differences. Results: The positive rates of AR in low-risk group and high-risk group were 57% and 66%, respectively. There was no significant difference between the two groups (P> 0.05). The positive rates of IGF-1R were 24% and 37% , The difference between the two groups was statistically significant (P <0.05). The positive rates of AR in high-risk group and low-risk group were 46% and 57%, respectively (P <0.05), the positive rates of IGF-1R were 26% and 34% There was no significant difference between the two groups (P> 0.05). The positive rates of AR in high-risk and low-risk groups were 46%, 54%, respectively. The positive rates of IGF-1R were 28%, 31% . CONCLUSION: AR protein expression in prostate cancer tissues increases at high-risk Gleason scores, and IGF-1R protein expression increases at high-risk clinical stages.