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由于病人选择方法、诊断标准、地理因素、随访时间和研究的设计不同,各家关于急性视神经炎(ON)后多发性硬化(MS)的发生率报导结果亦不同,通常在11.5%～85%之间。已经报导的危险因素有ON 的复发、某种HLA 抗原和脑脊液(CSF)中寡克隆带的出现。一般认为HLA-DW_2抗原与MS 发生密切有关。为了明确ON 后MS 的发生频率和危险因素,作者前瞻性研究了82例ON 病人,平均随访近5年,随访前后进行了组织型鉴定、临床检查和视觉诱发电位(VERs)。所有病例均排除中毒性、血管性或压迫性病变引起的视力衰退。全部病例均为高加索人,其中71
The incidence of multiple sclerosis (MS) after acute optic neuritis (ON) varies widely depending on patient selection method, diagnostic criteria, geographic factors, follow-up time, and design of the study, and is usually between 11.5% and 85% between. There have been reported risk factors for ON recurrence, presence of certain HLA antigens and oligoclonal bands in cerebrospinal fluid (CSF). It is generally believed that HLA-DW2 antigen is closely related to MS. To clarify the frequency and risk factors for MS after ON, 82 prospective ON patients were followed up for an average of nearly 5 years. Tissue identification, clinical examination and visual evoked potentials (VERs) were performed before and after follow-up. All cases ruled out toxic, vascular or oppression lesions caused by vision loss. All cases were Caucasian, of which 71